Jeffrey Howard Sheldon

Title: Innovations by Jeffrey Howard Sheldon

Introduction

Jeffrey Howard Sheldon is an accomplished inventor based in Trappe, PA (US). He has made significant contributions to the field of bladder function modulation, holding a total of 2 patents. His work focuses on developing methods and compounds that can improve bladder control and treat related conditions.

Latest Patents

Sheldon’s latest patents include innovative methods for selecting compounds that modulate bladder function. The first patent describes an assay system and method for selecting compounds useful in treating bladder instability through the activation of KCNQ potassium channels in bladder smooth muscle. The second patent provides methods and pharmaceutical compositions aimed at maintaining bladder control or treating urinary incontinence in mammals. This invention utilizes agonists of KCNQ potassium channels, including KCNQ2, KCNQ3, KCNQ4, and KCNQ5, either alone or in combination. Among the preferred compounds is N-[2-amino-4-(4-fluorobenzylamino)-phenyl]carbamic acid ethyl ester, commonly known as retigabine.

Career Highlights

Throughout his career, Sheldon has worked with notable companies such as Wyeth and American Home Products Corporation. His experience in these organizations has contributed to his expertise in pharmaceutical innovations.

Collaborations

Some of his notable coworkers include Thomas Michael Argentieri and Mark Robert Bowlby. Their collaborative efforts have further advanced the research and development of bladder function modulation.

Conclusion

Jeffrey Howard Sheldon is a prominent inventor whose work in bladder function modulation has led to valuable patents and advancements in the field. His contributions continue to impact the treatment of bladder-related conditions.