Jeffrey F Bonadio

Title: Innovations of Jeffrey F Bonadio

Introduction

Jeffrey F Bonadio is a notable inventor based in Ann Arbor, MI (US). He has made significant contributions to the field of biotechnology, holding a total of 9 patents. His work primarily focuses on the development of compositions and methods for the production of transformed cells, as well as sustained DNA delivery systems.

Latest Patents

One of his latest patents is titled "Composition and method for production of transformed cells." This invention describes a composition useful for producing transformed eukaryotic cells, which includes submucosal tissue and a nucleic acid sequence. The nucleic acid sequence typically comprises recombinant DNA that encodes one or more biofunctional proteins. The submucosal tissue component is derived from the tunica submucosa of vertebrate intestines, delaminated from the tunica muscularis, and includes at least the luminal portion of the tunica mucosa. The injection or implantation of this composition into a host induces the formation of transformed cells capable of expressing the genes encoded by the nucleic acid sequence.

Another significant patent is "Sustained DNA delivery from structural matrices." This patent discloses specific 3-dimensional structural matrices containing nucleic acids, along with various fabrication processes and methods for the prolonged release of nucleic acids in biological environments. The nucleic acid-matrix materials are designed to maintain a defined space, allowing for cellular migration, transfection, and proliferation in a controlled manner. The fabrication processes ensure high incorporation efficiencies and control over sustained nucleic acid release, making these matrices particularly useful in in vivo cell transfection and gene expression in gene therapy contexts.

Career Highlights

Jeffrey F Bonadio has worked at the University of Michigan, where he has contributed to various research projects and innovations in biotechnology. His expertise in the field has led to the development of groundbreaking technologies that have the potential to impact medical treatments and therapies.

Collaborations

Throughout his career, Bonadio has collaborated with notable individuals such as Steven A Goldstein and Stephen Francis Badylak. These collaborations have further enhanced his research and development efforts in the field of biotechnology.

Conclusion

Jeffrey F Bonadio is a distinguished inventor whose work in biotechnology has led to significant advancements in the production of transformed cells and sustained DNA delivery systems. His contributions continue to influence the field and hold promise for future medical