Company Filing History:
Years Active: 2003
Title: Jeffrey Edmond Cobb: Innovator in PPAR Antagonist Design
Introduction
Jeffrey Edmond Cobb, based in Durham, NC, is a notable inventor recognized for his significant contributions to the field of pharmacology. With one patent to his name, Cobb has developed innovative methods that enhance the understanding and application of PPAR antagonists.
Latest Patents
Cobb's patent focuses on the design of oxazole PPAR antagonists. This invention outlines a method for rationally designing antagonists by chemically modifying a PPAR, FXR, LXR-alpha, or LXR-beta agonist. The objective of this method is to prevent the formation of hydrogen bonds crucial for receptor activation or to displace amino acids involved in this process. One of the key aspects of Cobb's invention is that it creates antagonists as close structural analogues to the original agonists, aiming to minimize additional changes in the agonist's structure. Specific examples include compounds with various chemical modifications which can be utilized in pharmaceutical applications.
Career Highlights
Jeffrey Cobb has made significant advancements during his tenure at SmithKline Beecham Corporation, where he has focused on innovations in drug development. His work primarily centers around the rational design of pharmaceutical compounds that target specific receptors, which is crucial in the development of effective therapies.
Collaborations
Throughout his career, Cobb has worked alongside esteemed colleagues, including Millard Hurst Lambert III and Michael Vance Milburn. This collaborative environment has fostered a synergy that enhances innovative thinking and the refinement of drug design processes.
Conclusion
In summary, Jeffrey Edmond Cobb stands out as an inventor whose contributions to PPAR antagonist design reflect a deep understanding of pharmacological interactions. His work, particularly at SmithKline Beecham Corporation, emphasizes the importance of innovation in drug development, positioning him as a key figure in the field. With his patented method, Cobb is paving the way for future advancements in antagonist therapies.
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