Jeffrey A Mattis

Title: The Innovative Contributions of Jeffrey A. Mattis

Introduction

Jeffrey A. Mattis is a notable inventor based in West Chester, PA (US), recognized for his significant contributions to the field of biomedical engineering. With a total of 3 patents, he has made strides in the development of methods for labeling antibodies, which are crucial for various medical applications.

Latest Patents

One of his latest patents is a method for labeling antibodies with a metal ion. This innovative technique involves rapidly labeling sulfhydryl-containing antibodies or fragments with technetium or rhenium radioisotopes. The method combines an aqueous mixture of the radiometal in an oxidized form, a reducing agent, and a water-soluble polyhydroxycarbonylic acid ligand to form a stable complex of the radiometal in its reduced state. This mixture is then contacted with the sulfhydryl-containing antibody or fragment to produce a radiometal-labeled antibody or fragment. Another significant patent is for radiotherapeutic immunoconjugates labeled with iodine-125. This invention comprises a tumor-specific monoclonal antibody or fragment capable of tumor nucleus localization of the radionuclide, which is administered in a therapeutically effective amount to patients with malignancies.

Career Highlights

Throughout his career, Jeffrey has worked with prominent companies such as Centocor, Inc. and Centocor Cardiovascular Imaging Partners, L.P. His work in these organizations has contributed to advancements in medical imaging and therapeutic techniques.

Collaborations

Jeffrey has collaborated with notable professionals in his field, including Koon Y. Pak and Richard T. Dean. These collaborations have further enhanced his research and development efforts.

Conclusion

Jeffrey A. Mattis stands out as an influential inventor whose work has significantly impacted the biomedical field. His innovative patents and collaborations reflect his dedication to advancing medical technology.