Company Filing History:
Years Active: 1981-1994
Title: Jeffery H Robinson: Innovator in Hybrid Proteins
Introduction
Jeffery H Robinson is a notable inventor based in Epsom, GB. He has made significant contributions to the field of biotechnology, particularly in the development of hybrid proteins. With a total of 6 patents to his name, Robinson's work has the potential to impact pharmaceutical applications significantly.
Latest Patents
Robinson's latest patents include innovative designs for hybrid proteins of human plasminogen and human tissue plasminogen activator (t-PA). One of his notable inventions is a hybrid plasminogen activator that comprises the five kringle domains of plasminogen linked to the B-chain of t-PA or urokinase (u-PA). This invention features a unique amino acid sequence that connects the t-PA cleavage site and the cysteine residue of t-PA or u-PA. Additionally, he has developed a derivative of a plasminogen activator that includes a serine protease domain of t-PA or u-PA, with a catalytic site blocked by a 2-aminobenzoyl group. The hydrolysis rate constant for this derivative is measured in a specific buffer system, showcasing its potential efficacy. Another significant patent involves a fibrinolytically active hybrid protein that links chains from different proteases, ensuring that the hybrid maintains essential catalytic activity.
Career Highlights
Robinson is currently associated with Beecham Group Plc, where he continues to innovate in the field of biotechnology. His work has been instrumental in advancing the understanding and application of hybrid proteins in medical treatments.
Collaborations
Robinson has collaborated with notable colleagues, including Ian Dodd and Michael J Browne. Their combined expertise has contributed to the successful development of various innovative projects.
Conclusion
Jeffery H Robinson stands out as a significant figure in the field of hybrid protein research. His contributions through patents and collaborations have the potential to lead to groundbreaking advancements in pharmaceuticals.