Company Filing History:
Years Active: 2007-2012
Title: Jeff Darnell: Innovator in Electroporation and Biomaterial Production
Introduction
Jeff Darnell is a notable inventor based in The Woodlands, TX (US). He has made significant contributions to the fields of electroporation and biomaterial production. With a total of 2 patents, Darnell's work focuses on advancing technologies that facilitate the introduction of macromolecules into cells and the isolation of biologic products.
Latest Patents
Darnell's latest patents include a "Constant current electroporation device and methods of use." This electroporation device is designed to effectively introduce macromolecules into the cells of selected tissues in a body or plant. The device features an electro-kinetic device (EKD) that operates based on user-defined software or firmware. It produces programmable constant-current pulse patterns between electrodes in an array, allowing for the storage and acquisition of current waveform data. Additionally, the device includes a replaceable electrode disk with an array of needle electrodes, a central injection channel, and a removable guide disk.
Another significant patent is for "Devices and methods for biomaterial production." This apparatus and method isolate biologic products, such as plasmid DNA, from cells. The process involves lysing cells in a controlled manner to separate insoluble components from a fluid lysate. It employs membrane chromatographic techniques to purify cellular components of interest. The unique lysis apparatus includes a high shear, low residence-time mixer and an air-sparging bubble mixer, which thoroughly mixes lysed cells with a neutralization buffer.
Career Highlights
Throughout his career, Jeff Darnell has worked with several companies, including Vgx Pharmaceuticals, Inc. and Advisys, Inc. His experience in these organizations has contributed to his expertise in the development of innovative technologies.
Collaborations
Darnell has collaborated with notable individuals in his field, including Louis C. Smith and Ruxandra Draghia-Akli. These collaborations have further enhanced his work and contributions to the industry.
Conclusion
Jeff Darnell is a distinguished inventor whose work in electroporation and biomaterial production has led to significant advancements in the field. His innovative patents and career achievements reflect his commitment to improving technologies that benefit various applications.
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