Company Filing History:
Years Active: 1992
Title: Innovations of Jean deVilliers in Molecular Conjugates
Introduction
Jean deVilliers is an accomplished inventor based in Houston, TX (US). He has made significant contributions to the field of molecular biology, particularly in the development of molecular conjugates that enhance drug delivery systems. His innovative work focuses on creating conjugates that facilitate the attachment of macromolecular drugs to cellular surfaces, thereby improving their entry into cells.
Latest Patents
Jean deVilliers holds a patent for "Molecular conjugates containing cell membrane-blending agents." This patent describes molecular conjugates that enable the attachment of macromolecular drugs onto cellular surfaces. The conjugates consist of a macromolecular drug linked to an 'inactivated' membrane blending agent, which can insert into the cellular plasma membrane. The membrane blending agent is initially inactivated by a cleavable linkage to a blocking agent. This blocking agent prevents the blending agent from inserting into the cellular membrane until it is released under specific conditions. Once released, the membrane blending agent becomes 'activated,' allowing the conjugate to penetrate the cellular plasma membrane. The membrane blending agents can include peptides or long-chain fatty acids, while the blocking agents can be bulky or charged moieties.
Career Highlights
Jean deVilliers is currently associated with Tanox Biosystems, Inc., where he continues to advance his research in molecular conjugates. His work has the potential to revolutionize drug delivery methods, making treatments more effective and targeted.
Collaborations
Throughout his career, Jean has collaborated with notable colleagues, including Tse-wen Chang and Wayne Gordon. These partnerships have contributed to the development and refinement of his innovative ideas.
Conclusion
Jean deVilliers is a pioneering inventor whose work in molecular conjugates is paving the way for advancements in drug delivery systems. His contributions are significant in the field of molecular biology, and his patent reflects a commitment to improving medical treatments.