Jason Richard Harris

Title: Jason Richard Harris - Innovator in Gene Editing Technologies

Introduction

Jason Richard Harris is an inventor based in Durham, NC (US). He is known for his contributions to the field of gene editing, particularly in developing methods for treating alpha-1 antitrypsin (AAT) deficiency. Although he currently holds no granted patents, his innovative work is reflected in his latest patent applications.

Latest Patent Applications

1. **Gene Editing Methods for Treating Alpha-1 Antitrypsin (AAT) Deficiency** - This application discloses engineered meganucleases that bind and cleave a recognition sequence within the SERPINA1 gene, which encodes alpha-1 antitrypsin (AAT). It further includes donor polynucleotides that encode functional AAT proteins. The methods described involve using these engineered meganucleases and donor polynucleotides to create genetically-modified cells for the treatment of AAT deficiency.

2. **Optimized Polynucleotides for Protein Expression** - This application provides a method for expressing and delivering a polynucleotide encoding a protein of interest. The protein can be a nuclease associated with a gene-editing system, featuring an increased half-life of the mRNA encoding the engineered nuclease. This enhancement leads to increased protein levels and gene editing efficiency. The application also includes pharmaceutical compositions comprising the polynucleotides and methods for modifying the genome of eukaryotic cells.

Conclusion

Jason Richard Harris is making significant strides in the field of gene editing, with promising applications aimed at addressing critical health issues. His innovative approaches could pave the way for future advancements in genetic therapies.