Company Filing History:
Years Active: 2011
Title: Jasmid Tanha: Innovator in Brain-Targeting Antibody Fragments
Introduction
Jasmid Tanha is a notable inventor based in Ottawa, Canada. He has made significant contributions to the field of biotechnology, particularly in the development of innovative antibody fragments that target the brain. His work has the potential to revolutionize drug delivery systems for neurological conditions.
Latest Patents
Jasmid Tanha holds a patent for "Single-domain brain-targeting antibody fragments derived from llama antibodies." This invention involves a phage-displayed library of llama single heavy domain antibodies (sdAbs) that selectively bind to and are internalized by human cerebromicrovascular endothelial cells (HCEC). From this enriched library, two sdAbs were selected, sequenced, subcloned, and expressed as fusion proteins with c-myc-Histags. These soluble tagged sdAbs were shown to selectively bind to HCEC and to transmigrate across an in vitro human blood-brain barrier (BBB) model. Notably, these sdAbs were detected in the brain after intravenous injection into mice, demonstrating their potential as brain-specific delivery vectors for facilitating drug transport across the BBB. Jasmid Tanha's invention consists of small antibody fragments, approximately 13 kDa, which possess essential characteristics for effective drug delivery.
Career Highlights
Jasmid Tanha is affiliated with the National Research Council of Canada, where he continues to advance his research in antibody technology. His innovative work has garnered attention in the scientific community, contributing to the understanding of how to effectively deliver therapeutics to the brain.
Collaborations
Throughout his career, Jasmid has collaborated with esteemed colleagues, including Arumugam Muruganandam and Saran A Narang. These collaborations have further enriched his research and development efforts in the field of biotechnology.
Conclusion
Jasmid Tanha's contributions to the field of brain-targeting antibody fragments highlight his innovative spirit and dedication to advancing medical science. His work has the potential to significantly impact drug delivery systems for neurological diseases, paving the way for future advancements in this critical area of research.
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