Company Filing History:
Years Active: 1989
Title: Janice A. Light: Innovator in Plasmid Technology
Introduction: Janice A. Light is a notable inventor based in Henley-on-Thames, GB, recognized for her groundbreaking work in plasmid technology. With one patent to her name, she has made significant contributions to the field of biotechnology, specifically in the development of plasmids that exhibit conditional uncontrolled replication behavior.
Latest Patents: Janice A. Light holds a patent for "Plasmids with conditional uncontrolled replication behavior." This innovative invention introduces plasmids that are useful as cloning vectors, carrying an inserted regulatable promoter. The transcription from this promoter regulates plasmid replication, resulting in increased transcription that leads to a substantial or uncontrolled plasmid copy number when host microorganisms containing the plasmid are cultivated under specific conditions. The activator for this system is the temperature-sensitive λ cl repressor, which plays a vital role in managing plasmid copy numbers during microbial cultivation.
Career Highlights: Janice A. Light is associated with A/S Alfred Benzon, where her research has focused on enhancing plasmid vector systems. Her work aims to optimize the production of gene products by manipulating the temperature during cultivation. Specifically, host microorganisms are initially cultivated at around 30°C to maintain a constant low plasmid copy number, followed by a temperature shift to about 36°C-42°C to trigger an uncontrolled increase in plasmid copy number and amplify gene product yields.
Collaborations: Throughout her career, Janice has collaborated with esteemed colleagues, including Soren Molin and Jens E. Larsen. These collaborations have helped her refine her research and contribute valuable insights into the advancements in molecular biology and genetic engineering.
Conclusion: Janice A. Light represents a pioneering force in the field of molecular biotechnology. Her patented work on plasmid technology not only enhances our understanding of gene replication but also paves the way for more efficient gene product production. As she continues her work with A/S Alfred Benzon, her innovative spirit serves as an inspiration for aspiring inventors in the realm of biotechnology.