Company Filing History:
1 out of 22 
1 out of 517 
Years Active: 1997-2001
Title: Innovations by Jan McDonagh
Introduction
Jan McDonagh is an accomplished inventor based in Chestnut Hill, MA (US). She has made significant contributions to the field of medical science, particularly in the area of thrombolytic therapy. With a total of two patents to her name, her work focuses on enhancing the effectiveness of treatments for conditions related to blood clots.
Latest Patents
Jan McDonagh's latest patents include an assay for plasminogen activator inhibitor-1 and tissue plasminogen activator activity. This invention is based on the discovery that PAI-1 activity of a sample can be measured with sensitivity and correlation to in vivo activity without the use of standard curves. The assay determines the PAI-1 activity of a sample by utilizing the second order rate equation for the reaction of PAI-1 and t-PA, as measured by their activities in that sample. Another notable patent is for an improved method for enhancing the activity of thrombolytic agents, including t-PA, scu-PA, tcu-PA, and streptokinase. This method involves the supplementation of plasma plasminogen levels with deglycosylated forms of glu- and lys-plasminogen. The findings suggest that less glycosylated forms of plasminogen have a higher affinity for fibrin clots, which may lead to more effective thrombolytic therapy.
Career Highlights
Throughout her career, Jan has worked at prestigious institutions such as Beth Israel Hospital and Beth Israel Deaconess Medical Center, Inc. Her research has significantly impacted the field of thrombolytic therapy, providing new insights into the mechanisms of plasminogen and its role in clot dissolution.
Collaborations
Jan McDonagh has collaborated with notable colleagues, including Myoung H Lee and Marcin J Mankowski. These collaborations have further enriched her research and contributed to the advancements in her field.
Conclusion
Jan McDonagh's innovative work in the medical field, particularly in thrombolytic therapy, showcases her dedication to improving patient outcomes. Her patents reflect her commitment to advancing medical science and enhancing treatment methodologies.