Company Filing History:
Years Active: 1980-1992
Title: Jan J De Koning: Innovator in Cepham Derivatives
Introduction
Jan J De Koning is a notable inventor based in Rijswijk, Netherlands. He has made significant contributions to the field of pharmaceuticals, particularly in the development of cepham derivatives. With a total of 4 patents to his name, De Koning continues to push the boundaries of innovation in his area of expertise.
Latest Patents
De Koning's latest patents include a process for the preparation of 3-exomethylene cepham derivatives. This innovative process allows for the creation of 3-methylene and 3-halomethylene cepham derivatives through the use of 3-phosphoniomethyl-3-cephem derivatives. These derivatives can be synthesized from 3-halomethyl-3-cephem derivatives, and the preparation can be executed with or without isolating the intermediate phosphonium cephem compounds. Additionally, he has developed methods for preparing 3-exomethylenecepham sulfoxides and their derivatives, achieving high yield and purity through specific chemical reactions.
Career Highlights
Throughout his career, Jan J De Koning has been associated with Gist-Brocades N.V., where he has contributed to various research and development projects. His work has been instrumental in advancing the understanding and application of cepham compounds in the pharmaceutical industry.
Collaborations
De Koning has collaborated with several esteemed colleagues, including Jan Verweij and Hendrik A Witkamp. These partnerships have fostered a collaborative environment that encourages innovation and the sharing of ideas.
Conclusion
Jan J De Koning is a prominent figure in the field of pharmaceutical innovation, with a focus on cepham derivatives. His contributions through patents and collaborations highlight his commitment to advancing medical science. His work continues to inspire future innovations in the industry.