Company Filing History:
Years Active: 1978
Title: Jan Hakan Berglof: Innovator in Albumin Isolation
Introduction
Jan Hakan Berglof is a notable inventor based in Uppsala, Sweden. He has made significant contributions to the field of biochemistry, particularly in the isolation of albumin from blood products. His innovative methods have the potential to enhance the efficiency and purity of albumin extraction, which is crucial for various medical applications.
Latest Patents
Berglof holds a patent for a method of isolating albumin from blood products. This invention relates to a new method of isolating highly purified albumin in high yields from plasma products. According to the invention, a particular plasma fraction, containing albumin in dissolved form and being essentially free from the coagulation factors I, II, VII, VIII, IX, and X, and from the main part of IgG, is subjected to a two-step chromatographic separation using aqueous buffer systems. The first step is carried out on an anion exchanger, and the second step on a cation exchanger, or vice versa. In a preferred embodiment, a buffer of pH 4.5 - 4.9 and an ionic strength of 0.025 - 0.1 is used for the separation on the anion exchanger, whereas a buffer of pH 5.2 - 6.5 and an ionic strength of 0.1 - 0.05 is used for the separation on the cation exchanger. He has 1 patent to his name.
Career Highlights
Berglof is associated with Pharmacia Fine Chemicals AB, where he has been instrumental in advancing research and development in biopharmaceuticals. His work has contributed to the understanding and improvement of protein purification techniques, which are vital for therapeutic applications.
Collaborations
Throughout his career, Jan Hakan Berglof has collaborated with esteemed colleagues, including Lars-Olof Edvard Lindquist and John Malcolm Curling. These collaborations have fostered innovation and have led to advancements in the field of biochemistry.
Conclusion
Jan Hakan Berglof's contributions to the field of albumin isolation demonstrate his commitment to innovation in biochemistry. His patented method not only enhances the purity of albumin but also showcases the importance of collaboration in scientific research.