This inventor holds 3 USPTO granted patents. Top assignee: Sepracor, Inc.. Active years: 1999-2000.
Company Filing History:
Years Active: 1999-2000
Title: James Wallace Hilborn: Innovator in Fluoxetine Synthesis
Introduction
James Wallace Hilborn is a notable inventor based in Windsor, CA. He has made significant contributions to the field of chemistry, particularly in the synthesis of fluoxetine, a well-known antidepressant. With a total of 3 patents, Hilborn's work has had a lasting impact on pharmaceutical processes.
Latest Patents
Hilborn's latest patents include innovative methods for synthesizing fluoxetine. One patent details a process that begins with a lower alkyl ester of 3-benzoylpropionic acid, which is reduced in the presence of a chiral ligand to produce the corresponding gamma-hydroxy ester. This ester is then cleaved, and the free acid is condensed with alcohol to form a gamma-lactone. The process continues with treatment by ammonia to yield a gamma-hydroxy amide, which undergoes a Hoffman rearrangement to produce a 2-oxo-1,3 oxazine. This compound is then reduced to 3-(methylamino)-1-phenyl-1-propanol, which is further reacted to provide fluoxetine free base.
Another patent describes a synthesis of fluoxetine starting from benzoylacetonitrile. This process involves reducing the compound, optionally in the presence of a chiral ligand, to produce the corresponding aminoalcohol. The amine is then carbamoylated without isolation. The alcohol is deprotonated and reacted with 4-chloro- or 4-fluoro benzotrifluoride to create a carbamate of fluoxetine. This carbamate is subsequently reduced to yield fluoxetine free base, and the process can be employed for synthesizing individual enantiomers of fluoxetine.
Career Highlights
Throughout his career, Hilborn has worked with prominent companies such as Sepracor, Inc. and Sepacor Inc. His expertise in chemical synthesis has positioned him as a valuable asset in the pharmaceutical industry.
Collaborations
Hilborn has collaborated with notable colleagues, including Alex Roger Jurgens and Chris Hugh Senanayake. These partnerships have contributed to the advancement of his innovative work in fluoxetine synthesis.
Conclusion
James Wallace Hilborn's contributions to the field of chemistry, particularly in the synthesis of fluoxetine, highlight his innovative spirit and dedication to advancing pharmaceutical