Location History:
- Bethesda, MD (US) (1996 - 2002)
- Potomac, MD (US) (2002)
Company Filing History:
1 out of 14 
2 out of 832,812 Years Active: 1996-2002
Title: Innovations of James W. Shih
Introduction
James W. Shih is an accomplished inventor based in Bethesda, MD, known for his significant contributions to the field of nucleic acid diagnostics. With a total of three patents to his name, he has made notable advancements in the detection and quantification of target sequences in biological samples.
Latest Patents
One of his latest patents is titled "Nucleic acid hybridization assay utilizing tricyclic target and signal amplification." This invention focuses on nucleic acid-based diagnostic assays that detect, identify, and quantify target sequences in samples. It employs sequential cleavage of nucleic acids to achieve target and signal amplification through cycling reactions. Another significant patent is the "Method of amplifying DNA and RNA mismatch cleavage products." This method enhances the detection of probe fragment products of base pair mismatch cleavage, indicating the presence and sequence of target DNA. The detection process is improved by maintaining an assay temperature that allows for effective amplification through recycling targets, utilizing an amplifier such as ammonium acetate or an amine derivative.
Career Highlights
Throughout his career, James W. Shih has worked with various organizations, including the American Registry of Pathology. His work has been instrumental in advancing diagnostic techniques in molecular biology.
Collaborations
James has collaborated with notable professionals in his field, including Barbara Galvan and Jozsef Hepp. Their combined expertise has contributed to the success of his innovative projects.
Conclusion
James W. Shih's contributions to nucleic acid diagnostics through his patents reflect his dedication to advancing medical technology. His work continues to influence the field and improve diagnostic capabilities.