Company Filing History:
Years Active: 2000-2002
Title: Innovations of James Robert Knight
Introduction
James Robert Knight is a notable inventor based in Branford, CT (US). He has made significant contributions to the field of protein-protein interactions, holding 2 patents that showcase his innovative methods and systems.
Latest Patents
His latest patents focus on the identification and comparison of protein-protein interactions that occur in populations. The methods described involve detecting interactions among two populations of proteins, each with a complexity of at least 100. The encoded proteins are fused to either the DNA-binding domain or the activation domain of a transcriptional activator. By mating two yeast strains carrying different fusion proteins, productive interactions can lead to the reconstitution of the transcriptional activator, activating a reporter gene. This analysis can be extended to multiple populations of proteins, allowing for the characterization of genes involved in specific interactions relevant to various tissues, stages, or diseases. Additionally, inhibitors that interfere with these interactions are identified through their ability to inactivate a reporter gene, with screening conducted in a multiplexed format against a library of interactors. The patents also describe information-processing methods for assembling a unified database of protein-protein interaction data.
Career Highlights
James Robert Knight is associated with Curagen Corporation, where he applies his expertise in protein interactions to advance research and development in the field. His work has contributed to a deeper understanding of biological processes and potential therapeutic targets.
Collaborations
He has collaborated with notable colleagues, including Krishnan Nandabalan and Jonathan Marc Rothberg, enhancing the impact of his research through teamwork and shared expertise.
Conclusion
James Robert Knight's innovative work in protein-protein interactions has led to valuable patents that advance scientific knowledge and potential applications in medicine. His contributions continue to influence the field and inspire future research.
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