Location History:
- Los Angeles, CA (US) (2000)
- San Diego, CA (US) (1993 - 2005)
Company Filing History:
Years Active: 1993-2005
Title: The Innovative Contributions of James Richard Boulter in Neuroscience
Introduction
James Richard Boulter, located in San Diego, CA, is a prominent inventor with a remarkable portfolio of 11 patents. His work predominantly focuses on neuronal nicotinic acetylcholine receptors, contributing significantly to the field of neuroscience. Boulter's inventions are not only innovative but also pave the way for advancements in understanding neurological functions and developing therapeutic interventions.
Latest Patents
Among Boulter's recent patents is a groundbreaking invention related to neuronal nicotinic acetylcholine receptor compositions. This invention encompasses a family of receptors that include both neuronal agonist and non-agonist binding subunits. Notably, it features DNA sequences coding for agonist binding subunits like alpha2, alpha3, alpha4, and alpha5, along with non-agonist binding subunits beta2, beta3, and beta4. To facilitate further research, representative cDNA clones have been deposited with the American Type Culture Collection for patent purposes.
Another significant patent by Boulter is focused on the cloning and expression of a novel acetylcholine-gated ion channel receptor subunit. This patent includes isolated nucleic acids encoding the alpha9 nicotinic acetylcholine receptor subunit and the associated receptor subunit protein. It also provides vectors containing these nucleic acids, along with transformed host cells and transgenic non-human mammals that express this receptor subunit and its mutants. These receptors form cationic channels activated by acetylcholine, while being blocked by nicotine and muscarine, thereby contributing valuable methodologies for identifying compounds that modulate the ion channel activity.
Career Highlights
Boulter is currently associated with the Salk Institute for Biological Studies, a prestigious research institution renowned for its emphasis on biological research. His innovative work at the institute has significantly advanced the understanding of neuronal mechanisms and the development of potential treatments for neurological disorders.
Collaborations
Throughout his career, Boulter has collaborated with notable colleagues, including Stephen Fox Heinemann and James Warner Patrick. These collaborations have fostered an environment of shared expertise and have resulted in further advancements in the field of neuroscience.
Conclusion
James Richard Boulter stands out as a key innovator in the field of neuroscience. His extensive patent portfolio reflects a deep commitment to research and innovation, with inventions that significantly improve the understanding of neuronal functions. As he continues his work at the Salk Institute for Biological Studies, the contributions of Boulter are likely to influence both academic research and therapeutic applications in the years to come.