James R Smith is a notable inventor based in Bourbonnais, IL (US). He has made significant contributions to the field of biochemistry, particularly in the purification of alpha-1-antitrypsin (AAT) compositions. With a total of 7 patents to his name, Smith's work has implications for pharmaceutical applications and treatment methods.

Latest Patents

One of Smith's latest patents focuses on methods of treatment using alpha-1-antitrypsin compositions. This patent describes a streamlined method for purifying AAT from an AAT-containing protein mixture, such as Coh fraction IV precipitate. The method involves destabilizing contaminating proteins by cleaving disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are preferentially adsorbed on a solid protein-adsorbing material, eliminating the need for salt as a precipitant. The separation of the solid absorbent from the solution results in a purified AAT solution that is directly suitable for chromatographic purification, without extensive desalting as required in prior art processes. This innovative process provides pharmaceutical-grade AAT in high yield on a commercial scale.

Career Highlights

James R Smith is currently associated with CSL Behring GmbH, where he continues to advance his research and development efforts. His work has been instrumental in enhancing the efficiency of AAT purification processes, which are critical for therapeutic applications.

Collaborations

Smith has collaborated with notable colleagues, including Scott M Kee and Paul I Cook, to further his research initiatives and patent developments.

Conclusion

James R Smith's contributions to the field of biochemistry, particularly through his patents related to alpha-1-antitrypsin compositions, highlight his innovative approach to solving complex problems in pharmaceutical manufacturing. His work continues to impact the industry positively.

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