James R Goss

Title: Innovations of James R Goss

Introduction

James R Goss is an accomplished inventor based in Bethel Park, PA (US). He has made significant contributions to the field of biomedical engineering, particularly in the modulation of electrophysiological activity in excitable cells. With a total of 3 patents, his work has the potential to impact pain management and therapeutic interventions.

Latest Patents

One of his latest patents focuses on the targeted delivery of glycine receptors to excitable cells. This invention provides a method for modulating the electrophysiological activity of excitable cells by causing exogenous expression of a glycine receptor (GlyR) protein. The method involves exposing the excitable cell to an allosteric modulator of the GlyR protein, which in turn modulates the activity of the GlyR protein, an ion channel. This innovative approach can be utilized to control pain in subjects. Additionally, the invention includes a replication-defective HSV vector that comprises an expression cassette encoding a GlyR protein, along with stocks and pharmaceutical compositions containing such vectors, and a transgenic animal.

Career Highlights

James R Goss is affiliated with the University of Pittsburgh, where he continues to advance his research and innovations. His work is characterized by a strong focus on the intersection of molecular biology and electrophysiology, contributing to the understanding of pain mechanisms and potential treatments.

Collaborations

Throughout his career, Goss has collaborated with notable colleagues, including Michael Cascio and Joseph C Glorioso, III. These partnerships have fostered a collaborative environment that enhances the research output and innovation potential in their respective fields.

Conclusion

James R Goss exemplifies the spirit of innovation in the biomedical field through his groundbreaking patents and research. His contributions have the potential to significantly influence pain management strategies and improve patient outcomes.