James R Broughman

Title: Innovations of James R. Broughman

Introduction

James R. Broughman is an accomplished inventor based in Houston, TX (US). He has made significant contributions to the field of peptide research, holding a total of 2 patents. His work focuses on channel-forming peptides derived from the M2GlyR sequence, which have promising applications in enhancing cellular functions.

Latest Patents

Broughman's latest patents include innovative peptides that are modifications of the M2GlyR sequence. These peptides can be altered at their ends to incorporate a variety of polar amino acid residues, which improves their solubility. Notably, these peptides demonstrate enhanced effects on the transepithelial electrical resistance of cells at lower concentrations. The research indicates that these peptides can increase Isc in MDCK epithelial cell monolayers, achieving half-maximal effects at or below 30 µM, representing a nearly 10-fold improvement over previously characterized peptides in the M2GlyR family. Furthermore, these peptides have been shown to increase transepithelial electrical conductance and modulate the permeability of tight junctions in epithelial cells.

Career Highlights

James R. Broughman is affiliated with the Kansas State University Research Foundation, where he continues to advance his research in peptide technology. His work has garnered attention for its potential applications in various biomedical fields.

Collaborations

Broughman collaborates with notable colleagues such as Bruce D. Schultz and John M. Tomich, contributing to a dynamic research environment that fosters innovation.

Conclusion

James R. Broughman's contributions to peptide research exemplify the impact of innovative thinking in science. His patents reflect a commitment to advancing our understanding of cellular mechanisms and improving biomedical applications.