Company Filing History:
Years Active: 2013
Title: Innovations by James L Trevaskis
Introduction
James L Trevaskis is an accomplished inventor based in San Diego, California. He has made significant contributions to the field of medical science, particularly in the treatment of conditions related to body mass and metabolic disorders. His innovative work has led to the development of a patent that addresses critical health issues.
Latest Patents
James L Trevaskis holds a patent for "Methods to treat symptoms of pathophysiology related to body mass." This patent describes the expression of a mRNA encoding a putative 76 amino acid, secreted protein known as 'Enho1.' Research indicates that the expression of Enho1 negatively correlates with fasting triglyceride and cholesterol levels. By utilizing a recombinant adenovirus, Trevaskis was able to increase the expression of Enho1 mRNA in two mouse models of obesity, specifically KK-A and Lep/Lep mice. The results showed that over-expression of Enho1 through adenovirus injection significantly and reproducibly reduced fasting triglyceride and cholesterol levels in both models. Furthermore, transgenic mouse strains were developed to over-express the Enho1 protein. The study also revealed that the expression of a key gene involved in lipogenesis, fatty acid synthase, and FAS protein levels were reduced by ENHO1 adenoviral treatment in Lep/Lep mice. The full-length ENHO1 peptide, along with its derivatives, homologues, analogues, or mimetics, could potentially serve as therapeutic or diagnostic agents for various conditions, including hypercholesterolemia, hypertriglyceridemia, insulin resistance, obesity, diabetes, and energy imbalance.
Career Highlights
James L Trevaskis is affiliated with Louisiana State University and Agricultural & Mechanical College, where he continues to advance his research and innovations. His work has garnered attention for its potential impact on public health and the treatment of metabolic disorders.
Collaborations
One of his notable collaborators is Andrew A Butler, with whom he has worked on various research projects aimed at improving health outcomes through innovative treatments.
Conclusion
James L Trevaskis is a prominent inventor whose work in the field of metabolic health has the potential to transform treatment options for numerous conditions. His innovative approaches and research contributions continue to pave the way for advancements in medical science.