James J Rauh

Title: Innovations of James J Rauh in Insect Biology

Introduction

James J Rauh is a notable inventor based in Conowingo, MD (US), recognized for his contributions to the field of insect biology. He holds a total of 4 patents, showcasing his innovative approach to understanding and manipulating ryanodine receptors in various insect species.

Latest Patents

Rauh's latest patents focus on the isolation and use of ryanodine receptors. The genes encoding ryanodine receptor homologs have been characterized from multiple insect families. These genes and their corresponding polypeptides have numerous applications, including the development of screens to identify insecticidally active compounds. Additionally, methods are outlined for overcoming the toxic effects of expressing recombinant proteins in host cells. Another significant patent involves ryanodine receptor polypeptides, where the full-length genes have been isolated, cloned, and amplified in bacterial cells. Expression in insect cells demonstrates that the recombinant protein folds into a functional calcium release channel. The applications of these findings include the isolation of other pest ryanodine receptors and the identification of insecticides that disrupt calcium balance in cells.

Career Highlights

James J Rauh is currently employed at E.I. DuPont De Nemours and Company, where he continues to advance his research in insect biology. His work has significantly contributed to the understanding of ryanodine receptors and their potential applications in pest control.

Collaborations

Rauh has collaborated with notable colleagues such as Steven Gutteridge and Daniel Cordova, enhancing the scope and impact of his research.

Conclusion

James J Rauh's innovative work in the field of insect biology, particularly regarding ryanodine receptors, has paved the way for new methods in pest control and insect research. His contributions are vital to the ongoing development of effective insecticidal compounds.