James J Donovan

Title: Innovations of James J Donovan

Introduction

James J Donovan is a notable inventor based in Waukegan, IL. He has made significant contributions to the field of assay devices, holding a total of 3 patents. His work focuses on developing innovative methods for detecting analytes in various test samples.

Latest Patents

One of Donovan's latest patents involves assay devices for concurrently detecting an analyte and confirming the results. The novel analytical devices and methods he developed include dual pathway devices that provide confirmation of sandwich or competitive assay results. In a self-confirming sandwich assay, the labeled analyte complex becomes immobilized within a first pathway at an assay capture site, indicating the presence or amount of an analyte in the test sample. In a second pathway, a confirmatory reagent blocks the binding of the analyte or labeled analyte complex to a confirming assay site, thereby confirming that the presence of label in the assay capture site indicates a positive test sample. Additionally, in a self-confirming competitive assay, a confirmed positive result is characterized by a decrease in signal or no signal at the assay capture site, while the confirming assay site displays a detectable signal.

Another significant patent involves indicator reagents, diagnostic assays, and test kits employing organic materials. This patent describes an indicator reagent, assay method, and test kit for determining the presence or amount of an analyte in a test sample. The indicator reagent is formed by attaching an organic polymer latex particle, preferably a colored particle, to a specific binding member. The specific binding member can be adsorbed onto or covalently bound to the organic polymer latex particles, which are readily detected by direct visual observation or can be measured by appropriate instrumentation.

Career Highlights

James J Donovan has established a successful career at Abbott Laboratories Corporation, where he has been instrumental in advancing assay technology. His innovative approaches have contributed to the development of more efficient and reliable diagnostic tools.

Collaborations

Throughout his career, Donovan has collaborated with notable colleagues, including Peter J Tarcha and Martin Wong. These collaborations have further enhanced the impact of his inventions in the field of diagnostics.

Conclusion

James J Donovan's contributions to assay technology and his innovative patents have significantly advanced the field of diagnostics. His work continues to influence the development of new methods for detecting analytes in various applications.