Company Filing History:
9 out of 2,902 
7 out of 2,982 
Years Active: 1997-2000
Title: The Innovative Contributions of James Haseloff
Introduction
James Haseloff is a prominent inventor based in Cambridge, MA (US). He has made significant contributions to the field of biotechnology, particularly in the design and application of ribozymes. With a total of 9 patents to his name, Haseloff's work has paved the way for advancements in RNA manipulation and cell ablation techniques.
Latest Patents
One of Haseloff's latest patents focuses on "Cell ablation using trans-splicing ribozymes." This patent describes the design of new ribozymes capable of self-catalyzed trans-splicing, based on the catalytic core of a Group I intron. Using this innovative design, it is possible to construct ribozymes that can efficiently splice a new 3' exon sequence into any chosen target RNA sequence with high precision. Additionally, the patent outlines a method of cell ablation that provides a toxic product to a host cell in vivo in a targeted and regulated manner, utilizing the novel trans-splicing ribozymes he developed. Inactive pro-ribozyme forms are also described in this patent.
Another significant patent by Haseloff is centered on "Trans-splicing ribozymes." Similar to his previous work, this patent details the design of ribozymes capable of self-catalyzed trans-splicing, again based on the catalytic core of a Group I intron. This design allows for the efficient splicing of a new 3' exon sequence into any chosen target RNA sequence, ensuring high precision. Inactive pro-ribozyme forms are also discussed in this patent.
Career Highlights
Throughout his career, Haseloff has worked with esteemed institutions, including The General Hospital Corporation and Harvard College. His work has significantly impacted the field of molecular biology and biotechnology, leading to innovative solutions in RNA research.
Collaborations
Haseloff has collaborated with notable colleagues, including Howard M Goodman and Andrea Brand. These collaborations have further enriched his research and contributed to the advancement of his innovative projects.
Conclusion
James Haseloff's contributions to the field of biotechnology through his patents and collaborations highlight his role as a leading inventor. His work continues to influence the landscape of RNA manipulation and cell ablation techniques, showcasing the importance of innovation in scientific research.