This inventor holds 1 USPTO granted patent. Top assignee: Oncogen. Active years: 1992.
Company Filing History:
Years Active: 1992
Title: James G. Bradley: Innovator in Cell Growth Regulation
Introduction
James G. Bradley is a notable inventor based in Woodinville, WA (US). He has made significant contributions to the field of biotechnology, particularly in the area of cell growth regulation. His innovative work has implications for both cancer treatment and wound healing.
Latest Patents
James G. Bradley holds a patent for a bifunctional growth modulating glycoprotein known as Amphiregulin. This novel cell growth regulatory factor is characterized by its median molecular weight of 22,500 daltons and its unusual biological activity. Amphiregulin exhibits potent inhibitory effects on DNA synthesis in neoplastic cells while simultaneously promoting the growth of certain normal cells. The invention is based on the discovery that MCF-7 cells, when treated with the tumor-promoting agent 12-O-tetradecanoyl-phorbol-13-acetate (TPA), express and secrete two distinct yet functionally equivalent forms of Amphiregulin. These forms are structurally identical, with the truncated version lacking an amino-terminal hexapeptide found in the larger form. The Amphiregulin gene has been cloned and utilized to construct plasmids that direct the expression of bioactive Amphiregulin in transformed Escherichia coli cells. The potential applications for Amphiregulin include the treatment of wounds and various cancers.
Career Highlights
James G. Bradley is associated with Oncogen, a company focused on cancer research and treatment. His work has positioned him as a key figure in the development of innovative therapeutic strategies.
Collaborations
James has collaborated with notable colleagues, including Vicki Lynn McDonald and Mohammed Shoyab, contributing to advancements in their shared field of research.
Conclusion
James G. Bradley's contributions to the field of biotechnology, particularly through his patent for Amphiregulin, highlight his role as an innovator in cell growth regulation. His work has the potential to impact cancer treatment and wound healing significantly.