Location History:
- Carrboro, NC (US) (2001)
- Eagan, MN (US) (2002)
Company Filing History:
2 out of 832,891 Years Active: 2001-2002
Title: Innovations of James E Rider
Introduction
James E Rider is an accomplished inventor based in Eagan, MN (US). He has made significant contributions to the field of biochemistry, particularly through his work on peptides that bind to Src homology region 3 (SH3) domains of proteins. With a total of 2 patents, Rider's innovations have the potential to impact various applications in molecular biology and therapeutic development.
Latest Patents
Rider's latest patents include the development of Nck SH3 binding peptides. These peptides exhibit general and specific binding affinities for SH3 domains of proteins. The invention details the isolation of SH3 binding peptides from phage-displayed random peptide libraries, which were screened for their ability to bind to bacterial fusion proteins containing an SH3 domain and glutathione S-transferase (GST). The preferred peptides consist of a core 7-mer sequence, along with additional amino acid residues, resulting in a total length of 9 to 45 amino acid residues. These peptides demonstrate preferential binding affinities for specific SH3 domains, particularly those associated with the Src-family of proteins. In vitro and in vivo results validate the biochemical activity of these peptides.
Another notable patent by Rider focuses on GRB2 SH3 binding peptides. Similar to his previous work, this invention also involves peptides with binding affinities for SH3 domains. The methodology for isolating these peptides and their applications are discussed in detail. The preferred peptides again comprise a core sequence and additional residues, showcasing their specific binding capabilities for Src-family proteins.
Career Highlights
Throughout his career, James E Rider has been dedicated to advancing the understanding of protein interactions through innovative peptide design. His work has contributed to the broader field of molecular biology, providing insights that could lead to new therapeutic strategies.
Collaborations
Rider has collaborated with notable colleagues, including Andrew B Sparks and Brian K Kay. These partnerships have likely enriched his research and expanded the impact of his inventions.
Conclusion
James E Rider's contributions to the field of biochemistry through his innovative peptide designs highlight his role as a significant inventor. His patents on SH3 binding peptides demonstrate the potential for advancements in molecular biology and therapeutic applications.