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Title: James E Haber: Innovator in Genetic Engineering
Introduction
James E Haber is a notable inventor based in Waltham, MA (US). He has made significant contributions to the field of genetic engineering, particularly in the area of multiplex production and barcoding of genetically engineered cells. His innovative work has implications for high-throughput genome editing and the precise modification of genetic material.
Latest Patents
Haber holds a patent for "Multiplex production and barcoding of genetically engineered cells." This patent describes a system that utilizes RNA-guided nucleases and genomic barcoding to achieve high-throughput multiplex genome editing. The method allows for precise genome editing at desired target chromosomal loci through homology directed repair. By integrating guide RNA and donor DNA sequences as a genomic barcode, it enables the identification, isolation, and validation of individual variants from a pool of transformants. This innovative approach facilitates the arraying of strains according to their specific genetic modifications.
Career Highlights
Throughout his career, James E Haber has worked with prestigious institutions such as Leland Stanford Junior University and Brandeis University. His research has focused on advancing the techniques used in genetic engineering, contributing to the development of methods that enhance homology directed repair and enable complete saturation mutagenesis of protein-coding genes.
Collaborations
Haber has collaborated with notable colleagues, including Kevin Roy and Justin D Smith. These collaborations have further enriched his research and contributed to the advancements in genetic engineering.
Conclusion
James E Haber is a pioneering inventor whose work in genetic engineering has led to significant advancements in the field. His patent on multiplex production and barcoding of genetically engineered cells exemplifies his innovative approach to genome editing. His contributions continue to influence research and applications in genetic engineering.