James D Rozzell, Jr

Title: James D Rozzell, Jr: Innovator in Chiral Amines Synthesis

Introduction

James D Rozzell, Jr. is a notable inventor based in Warren, NJ (US). He has made significant contributions to the field of chemistry, particularly in the synthesis of chiral amines. His innovative work has led to the development of a patented process that enhances the efficiency of producing these important compounds.

Latest Patents

James D Rozzell, Jr. holds a patent for "Enantiomeric enrichment and stereoselective synthesis of chiral amines." This patent describes a method for enriching amines in which the amino group is on a secondary carbon atom that is chirally substituted. The process utilizes an omega-amino acid transaminase to preferentially convert one of the two chiral forms to a ketone. This method allows for the stereoselective synthesis of one chiral form from ketones, substantially excluding the other. The process involves treating an aqueous solution of chiral amines with the transaminase and an amino acceptor, followed by separation of the aqueous and organic phases for further processing.

Career Highlights

James D Rozzell, Jr. is associated with Celgene Corporation, where he has contributed to advancements in pharmaceutical chemistry. His work has been instrumental in developing methods that enhance the production of chiral compounds, which are crucial in the development of various medications.

Collaborations

Throughout his career, James has collaborated with notable colleagues, including David I Stirling and Andrew L Zeitlin. These collaborations have fostered an environment of innovation and have led to significant advancements in their respective fields.

Conclusion

James D Rozzell, Jr. is a distinguished inventor whose work in the synthesis of chiral amines has made a lasting impact on the field of chemistry. His patented processes demonstrate the importance of innovation in developing efficient methods for producing essential compounds.