James B Rottman

Title: Innovations in Immunology: The Patented Work of James B Rottman

Introduction

James B Rottman, an inventor based in Sudbury, MA, has made notable contributions to the field of immunology through his innovative patent. With a profound understanding of T cell dynamics, Rottman's work focuses on the modulation of systemic memory T cell trafficking, a critical aspect of immune response regulation.

Latest Patents

Rottman's sole patent titled "Modulation of Systemic Memory T Cell Trafficking" presents methods to specifically modulate the trafficking of systemic memory T cells, particularly CD4+ T cells. His invention is significant as it allows for the selective manipulation of systemic memory T cells while preserving the integrity of naive T cells and intestinal memory T cells. The innovation showcases the use of CCR4 ligands such as TARC and MDC, which act as adhesion triggers, leading to integrin-dependent arrest and localizing T cells at target sites. The patent provides insights into enhancing T cell localization using CCR4 agonists or blocking CCR4 activity with antagonists.

Career Highlights

Through his career, James B Rottman has established himself as a leading inventor in immunotherapy. His understanding of T cell behavior and trafficking has paved the way for potential advancements in therapeutic strategies aimed at enhancing immune responses.

Collaborations

Throughout his career, Rottman has collaborated with esteemed colleagues such as Eugene C Butcher and James J Campbell. These partnerships have fostered innovative research and development in the realm of immune modulation, contributing to the advancement of immunological sciences.

Conclusion

James B Rottman's patent reflects a significant step forward in the understanding and manipulation of T cell trafficking, offering potential applications in immunotherapy. His focused work demonstrates the intersection of innovative thinking and scientific inquiry, placing him among the notable inventors in the field of immunology.