This inventor holds 1 USPTO granted patent. Top assignees: University of California, University of Illinois. Active years: 2018.
Company Filing History:
1 out of 15,988 
1 out of 2,421 
Years Active: 2018
Title: Innovations in Antibacterial Compounds by James Andrew McCammon
Introduction
James Andrew McCammon is an accomplished inventor based in La Jolla, California. He has made significant contributions to the field of antibacterial treatments, particularly in response to the growing issue of antibiotic resistance. His innovative work focuses on developing new compounds that can effectively combat resistant bacterial strains.
Latest Patents
One of McCammon's notable patents is for antibacterial compounds targeting isoprenoid biosynthesis. This invention addresses the urgent need for new drugs as resistance to antibiotics like methicillin continues to rise. The patent describes small molecules that inhibit critical cellular drug targets, such as UPPS and FPPS, by interacting with their binding pockets. This interaction prevents enzyme function, making these compounds effective against bacteria with a minimum inhibitory concentration (MIC90) of less than 0.25 µg/mL. Furthermore, these compounds can synergize potently with methicillin, as indicated by a fractional inhibitory concentration index of 0.25. In preclinical studies, they have shown protective effects in mouse infection models. This invention provides a promising avenue for developing antibacterial treatments and restoring sensitivity to existing drugs through combination therapies.
Career Highlights
Throughout his career, McCammon has worked at prestigious institutions, including the University of Illinois and the University of California. His research has focused on innovative solutions to combat bacterial infections, contributing to the advancement of medical science.
Collaborations
McCammon has collaborated with notable colleagues, including Kai Li and Eric Oldfield. These partnerships have further enriched his research and development efforts in the field of antibacterial compounds.
Conclusion
James Andrew McCammon's work in developing antibacterial compounds represents a significant advancement in the fight against antibiotic resistance. His innovative approaches and collaborations have the potential to lead to effective new treatments for bacterial infections.