Company Filing History:
Years Active: 2006-2011
Title: The Innovations of James A. Johnston
Introduction
James A. Johnston is a notable inventor based in Middletown, MD (US). He has made significant contributions to the field of immunology, particularly through his work on Janus family kinases. With a total of 3 patents, Johnston's research has advanced our understanding of immune modulation.
Latest Patents
Johnston's latest patents focus on the Janus family kinases and the identification of immune modulators. One of his key inventions involves an isolated polynucleotide that encodes the JAK-3 protein. This protein is a protein tyrosine kinase with a molecular weight of approximately 125 kDa. It features tandem non-identical catalytic domains and notably lacks SH2 or SH3 domains. JAK-3 is expressed in natural killer (NK) cells and stimulated or transformed T cells, but not in resting T cells. The patent also presents the protein itself and antibodies to this protein. Furthermore, it outlines methods for identifying therapeutic agents that can modulate the immune system.
Career Highlights
James A. Johnston is affiliated with the National Institutes of Health, a component of the US Department of Health & Human Services. His work at this prestigious institution has allowed him to explore groundbreaking research in immunology and therapeutic development.
Collaborations
Johnston has collaborated with esteemed colleagues such as John J. O'Shea and Warren Jaye Leonard. These partnerships have further enriched his research and contributed to the advancement of knowledge in the field.
Conclusion
James A. Johnston's innovative work in immunology, particularly regarding JAK-3 protein and immune modulation, showcases his significant impact on the scientific community. His contributions continue to pave the way for future advancements in therapeutic interventions.