James A Crawford

Title: Innovations by James A Crawford

Introduction

James A Crawford is an accomplished inventor based in Hilliard, OH (US). He has made significant contributions to the field of protein solubility, which has important implications in biotechnology and medicine. His innovative work focuses on improving the solubility of proteins, particularly bacterial toxins, which can enhance their utility in various applications.

Latest Patents

James A Crawford holds a patent for "Proteins with improved solubility and methods for producing and using same." This patent describes a method for enhancing the solubility of proteins by introducing point mutations that replace cysteine residues capable of forming intermolecular disulfide bonds. By preventing these bonds, the aggregation of proteins is reduced, leading to improved solubility. Additionally, the patent outlines the production of truncated forms of proteins that express specific domains, making them useful as immunodiagnostic agents and vaccine components. He has 1 patent to his name.

Career Highlights

Crawford is associated with the Health Protection Agency, where he applies his expertise in protein chemistry to advance public health initiatives. His work has the potential to impact vaccine development and diagnostic tools, showcasing the importance of his research in the medical field.

Collaborations

James A Crawford has collaborated with Clifford Charles Shone, contributing to the advancement of their shared research interests. Their partnership exemplifies the collaborative spirit often found in scientific research.

Conclusion

James A Crawford's innovative work in protein solubility represents a significant advancement in biotechnology. His contributions have the potential to enhance the effectiveness of vaccines and diagnostic agents, making a lasting impact on public health.