Location History:
- Fayettesville, NY (US) (1986)
- Fayetteville, NY (US) (1977 - 1988)
- Cheshire, CT (US) (1991)
Company Filing History:
Years Active: 1977-1991
Title: The Innovative Contributions of James A. Bush
Introduction
James A. Bush is a notable inventor based in Fayetteville, NY (US), recognized for his significant contributions to the field of pharmaceuticals. With a total of 14 patents to his name, he has made remarkable strides in developing antitumor antibiotics that have the potential to impact cancer treatment.
Latest Patents
Among his latest patents is the antitumor antibiotic kedarcidin. Kedarcidin is a protein antitumor antibiotic produced by Streptoalloteichus sp. nov. strain L585-6, ATCC 53650. This antibiotic comprises a non-protein chromophore and a single chain polypeptide having 114 amino acid residues. Another significant patent is the rigolettone antitumor complex. This novel complex, designated as rigolettone complex, is produced by fermentation of Streptomyces aburaviensis strain C-38,242 (ATCC 39290). The complex and its purified bioactive components, jildamycin and mantuamycin, exhibit antitumor activity in mouse tumor systems.
Career Highlights
James A. Bush is currently associated with Bristol-Myers Company, where he continues to innovate and contribute to the field of cancer research. His work has been instrumental in advancing the understanding and treatment of various tumors.
Collaborations
Throughout his career, James has collaborated with esteemed colleagues, including Donald E. Nettleton, Jr. and William T. Bradner. These collaborations have further enriched his research and development efforts.
Conclusion
James A. Bush's innovative work in the development of antitumor antibiotics showcases his dedication to improving cancer treatment. His contributions are invaluable to the pharmaceutical industry and the ongoing fight against cancer.