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For the Inventor, By the Inventor

Ann Arbor, MI, United States of America

James A Bristol

USPTO Granted Patents = 23

Average Co-Inventor Count = 2.1

ph-index = 11

Forward Citations = 370(Granted Patents)


Company Filing History:

goldMedal15 out of 2,538 
 
Warner-lambert Company
 patents
silverMedal8 out of 1,829 
 
Schering Corporation
 patents

Years Active: 1982-1989

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23 patents (USPTO):Explore Patents
1. 4820697 - 4,5-dihydro-4,4-dialkyl-6-(substituted)phenyl-3(2H)-pyridazinones useful (1989-04-11),
2. 4734415 - Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and (1988-03-29),
3. 4717730 - 4,5-dihydro-6-(substituted)phenyl-5-methyl-3-(2H)-pyridazinones and (1988-01-05),
4. 4701453 - Substituted indeno-pyridazinones (1987-10-20),
5. 4663313 - N.sup.6 -tricyclic adenosines for treating hypertension (1987-05-05),
6. 4657898 - N.sup.6 -substituted adenosines and method of use (1987-04-14),
7. 4657897 - N.sup.6 -substituted adenosines for treating pain (1987-04-14),
8. 4626526 - (S)-N.sup.6 -2-hydroxypropyladenosines (1986-12-02),
9. 4607037 - Cardiotonic 2(1H)-pyridinones (1986-08-19),
10. 4602019 - Indeno[1,2-c]pyridazin-3-one derivatives useful as cardiotonic and (1986-07-22),
11. 4593019 - N.sup.6 -tricyclic adenosines (1986-06-03),
12. 4521416 - 4,5-Dihydro-6-[(substituted)-1H-imidazol-4-yl or (1985-06-04),
13. 4507294 - Imidazo[1,2-a]pyrazines (1985-03-26),
14. 4503061 - Substituted phenyl-pyridinones as cardiotonic agents (1985-03-05),
15. 4464372 - Imidazo[1,2-b]pyridazines (1984-08-07),

Title: James A. Bristol: Innovating Cardiovascular Treatments in Ann Arbor, MI

Introduction

James A. Bristol is a prominent inventor based in Ann Arbor, MI, whose significant contributions to the field of medicinal chemistry are exemplified by his 23 patents. His innovative research focuses on developing compounds with cardiotonic and antihypertensive properties, pivotal in the treatment of heart-related ailments.

Latest Patents

Among his latest inventions, Bristol has developed several novel compounds including 4,5-dihydro-4,4-dialkyl-6-(substituted)phenyl-3(2H)-pyridazinones which exhibit unexpected activity as potential cardiotonic and antihypertensive agents. These compounds have demonstrated a significant increase in myocardial contractility in canine models and a decrease in blood pressure in spontaneously hypertensive rat models. The process for synthesizing these compounds involves reacting substituted .gamma.-oxobenzenebutanoic acids with appropriately substituted hydrazines, resulting in 4,5-dihydro-6-(substituted)phenyl-3(2H)-pyridazinones, followed by dehydrogenation to yield 6-(substituted)phenyl-3(2H)-pyridazinones, both of which hold promise as therapeutic agents.

Career Highlights

Bristol's illustrious career includes tenures at notable pharmaceutical companies such as Warner-Lambert Company and Schering Corporation. His work at these organizations has been instrumental in advancing the understanding and development of cardiovascular therapies.

Collaborations

Throughout his career, James A. Bristol has collaborated with esteemed colleagues including Ila Sircar and Raymond G. Lovey. Their joint efforts have contributed to the fruitful research environment that fosters innovation and discovery in the field of pharmaceutical sciences.

Conclusion

James A. Bristol's contributions to the field of medicinal chemistry and his focus on cardiovascular treatments underscore his status as a pioneering inventor. With a robust portfolio of patents and collaborations with leading professionals in the industry, Bristol continues to make a significant impact in the realm of health sciences.

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