Company Filing History:
Years Active: 2021
Title: Innovations by Jamal Chauhan in Antibiotic Development
Introduction
Jamal Chauhan is an accomplished inventor based in Baltimore, MD, known for his significant contributions to the field of antibiotic research. With a total of two patents to his name, he has focused on developing novel compounds that combat resistant bacterial strains.
Latest Patents
Chauhan's latest patents revolve around small molecule lipid II inhibitors. Newly synthesized derivatives of BAS00127538 have been discovered to possess antibiotic activity and combat resistant bacterial strains. These compounds and pharmaceutical compositions are based on a generic scaffold structure. The preferred compound, 6jc48-1, binds to Lipid II with high affinity, demonstrating markedly reduced cytotoxicity compared to BAS00127538. It retains activity against drug-resistant strains and is stable in plasma, showcasing dramatically improved pharmacokinetic and pharmacodynamic properties. Additionally, it possesses in vivo efficacy in a mouse model of sepsis.
Career Highlights
Chauhan is affiliated with the University System of Maryland, where he continues to advance his research in antibiotic development. His work has the potential to significantly impact the treatment of bacterial infections, particularly those that are resistant to existing antibiotics.
Collaborations
Some of his notable coworkers include Erik De Leeuw and Alexander MacKerell, who contribute to the collaborative efforts in his research endeavors.
Conclusion
Jamal Chauhan's innovative work in developing small molecule lipid II inhibitors represents a promising advancement in the fight against antibiotic resistance. His contributions are vital in addressing one of the most pressing challenges in modern medicine.