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For the Inventor, By the Inventor

Milford, OH, United States of America

J O'Neal Johnston

USPTO Granted Patents = 14

Average Co-Inventor Count = 2.2

ph-index = 3

Forward Citations = 44(Granted Patents)


Location History:

  • Cincinnati, OH (US) (1981)
  • Milford, OH (US) (1982 - 1996)

Company Filing History:

goldMedal14 out of 455 
 
Merrell Dow Pharmaceuticals
 patents

Years Active: 1981-1996

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14 patents (USPTO):Explore Patents
1. 5491136 - 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aromatase, (1996-02-13),
2. 5486511 - 4-amino-17.beta.-(cyclopropyloxy)androst-4-en-3-one, (1996-01-23),
3. 5252565 - Haloethyl-substituted steroid enzyme inhibitors (1993-10-12),
4. 5166201 - 2.beta.,19-ethylene bridged steroids as aromatase inhibitors (1992-11-24),
5. 5126488 - 2.beta.,19-methyleneamino bridged steroids as aromatase inhibitors (1992-06-30),
6. 5099037 - 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aromatase (1992-03-24),
7. 4954491 - Method of treatment using 18-cyanoprogesterone derivatives (1990-09-04),
8. 4954488 - Method of treating hyperaldosteronism using (1990-09-04),
9. 4920114 - 19-fluoro- or cyano-21-hydroxyprogesterone derivatives useful as (1990-04-24),
10. 4910191 - 19-substituted progesterone derivatives useful as 19-hydroxylase (1990-03-20),
11. 4882322 - 3.beta.,17.beta.-hydroxy-substituted steroids and related steroidal (1989-11-21),
12. 4322416 - 10-Alkynyl steroids (1982-03-30),
13. 4293548 - 18-Substituted pregn-4-ene-3,20-diones (1981-10-06),
14. 4289762 - 10-(1,2-Propadienyl) steroids as irreversible aromatase inhibitors (1981-09-15),

Title: The Innovative Contributions of J O'Neal Johnston

Introduction

J O'Neal Johnston, an accomplished inventor based in Milford, OH, has made significant strides in the field of pharmaceuticals and chemical compounds. With a remarkable portfolio of 14 patents, his work focuses on the development of steroidal compounds that serve as crucial inhibitors in the treatment of various estrogen-dependent disorders.

Latest Patents

Johnston’s latest patents showcase his expertise in innovative steroidal chemistry. One of his notable inventions involves the use of 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as inhibitors of the enzyme steroid aromatase and 19-hydroxylase. This method holds promise as a treatment for hormonal-dependent breast cancer and other related disorders.

Another significant patent is centered around compounds such as 4-amino-17 beta-(cyclopropyloxy)androst-4-en-3-one and 4-amino-17 beta-(cyclopropylylamino)androst-4-en-3-one. These compounds, along with their synthesis processes, provide therapeutic avenues for conditions like benign prostatic hyperplasia, breast cancer, and prostatic cancer. The synthesis employs a unique reaction of 4,5-epoxides with sodium azide in an inert solvent, showcasing Johnston's innovative approach to pharmaceutical development.

Career Highlights

J O'Neal Johnston has dedicated his career to advancing pharmaceutical sciences, particularly through his work at Merrell Dow Pharmaceuticals. His role has allowed him to focus on creating and patenting pharmaceutical formulations that can significantly improve patient outcomes.

Collaborations

Throughout his career, Johnston has collaborated with notable peers, including Norton P Peet and Joseph P Burkhart. These partnerships have contributed to the development of groundbreaking patents and have facilitated the sharing of expertise within the domain of steroid chemistry.

Conclusion

J O'Neal Johnston's contributions to the field of pharmaceuticals through his innovative patents have established him as a key player in the fight against hormone-related disorders. His work not only showcases his inventiveness but also his commitment to advancing medical science for the benefit of patients.

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