Company Filing History:
3 out of 1,587 
1 out of 3,288 Years Active: 1990-2014
Title: J Evan Sadler: Innovator in Biochemical Research
Introduction
J Evan Sadler is a notable inventor based in St. Louis, MO, with a focus on biochemical innovations. He holds three patents that contribute significantly to the field of medical research, particularly in understanding and measuring specific enzyme activities.
Latest Patents
One of his latest patents is titled "Fluorogenic substrate for ADAMTS13." This invention discloses fluorogenic substrates designed for measuring ADAMTS13 activity or inhibitor activity. The substrates consist of an oligopeptide that can include up to 80 amino acids from the sequence of von Willebrand Factor (VWF). Modifications to the VWF sequence include an amino-terminal glycine, a scissile Y-M peptide, and a cysteine substitution. The substrate also features a fluorophore and a fluorescence quencher bound to the oligopeptide on opposite sides of the scissile Y-M peptide. Additionally, the oligopeptide can be encoded by a nucleic acid sequence that may also encode a His tag, and it can be expressed in a cell or microorganism. Another significant patent involves DNA clones of human placental plasminogen activator inhibitor. This patent details cDNA clones with a base sequence for human placental plasminogen activator inhibitor (PAI-2), which has been characterized and expressed in both prokaryotic and eukaryotic cells.
Career Highlights
Throughout his career, J Evan Sadler has worked with prestigious institutions, including Washington University. His research has led to advancements in understanding enzyme activities that are crucial for various medical applications.
Collaborations
He has collaborated with notable colleagues such as Philip W Majerus and Tze-Chein Wun, contributing to a rich environment of innovation and research.
Conclusion
J Evan Sadler's contributions to biochemical research through his patents and collaborations highlight his role as an influential inventor in the field. His work continues to impact medical research and enzyme activity measurement.