Location History:
- Naruto, JP (1996)
- Tokushima, JP (1999 - 2010)
Company Filing History:
3 out of 138 
2 out of 167 
1 out of 318 
Years Active: 1996-2010
Title: The Innovative Contributions of Isao Wada
Introduction
Isao Wada is a notable inventor based in Tokushima, Japan. He has made significant contributions to the field of chemistry, particularly in the development of processes related to penam compounds and penicillin crystals. With a total of five patents to his name, Wada's work has had a considerable impact on pharmaceutical manufacturing.
Latest Patents
One of Wada's latest patents is a process for producing a penam compound that is useful for preparing tazobactam. The objective of this invention is to provide an industrially advantageous process that remarkably suppresses the generation of an undesirable by-product, cepham compound. This is achieved by reacting a diphenylmethyl 2β-bromomethyl-2α-methylpenam-3α-carboxylate (BMPB) with 1,2,3-triazole in a halogenated hydrocarbon solvent at -5°C or lower. This method allows for the efficient production of the desired diphenylmethyl 2α-methyl-2β-[(1,2,3-triazol-1-yl)methyl]penam-3α-carboxylate (TMPB).
Another significant patent involves the production of penicillin crystals. This invention provides 2β-chloromethyl-2α-methylpenam-3α-carboxylic acid benzhydryl ester (CMPB) crystals that exhibit excellent stability. The process for producing these CMPB crystals includes several steps: concentrating a solution containing CMPB, subjecting the concentrate to column chromatography, concentrating a CMPB-containing fraction, and finally dissolving the concentrate in an ether solvent before adding a hydrocarbon solvent to precipitate the CMPB crystals.
Career Highlights
Isao Wada has worked with prominent companies in the pharmaceutical industry, including Otsuka Kagaku Kabushiki Kaisha and Otsuka Chemical Co., Ltd. His experience in these organizations has contributed to his expertise in the field of chemical processes and innovations.
Collaborations
Throughout his career, Wada has collaborated with notable colleagues such as Michio Sasaoka and Yutaka Kameyama. These collaborations have likely enriched his research and development efforts, leading to innovative solutions in his field.
Conclusion
Isao Wada's contributions to
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