Company Filing History:
Years Active: 2013
Title: Irvin Sy Chen: Innovator in Gene Therapy and RNA Delivery Systems
Introduction
Irvin Sy Chen is a notable inventor in the field of gene therapy and RNA delivery systems. His work focuses on developing innovative methods and materials that enhance the targeting abilities of viral vectors and improve the delivery of RNA molecules for therapeutic applications.
Latest Patents
Chen's latest patents include "Viral Vector Nanocapsule For Targeting Gene Therapy And Its Preparation." This invention provides novel methods, materials, and systems for generating viral vectors with altered tissue and cell targeting abilities. The specificity of lentiviral vectors is modulated by a thin polymer shell that is synthesized and coupled to the viral envelope in situ. This polymer shell confers new targeting abilities via agents such as cyclic RGD (cRGD) peptides. These polymer-encapsulated viral vectors exhibit desirable characteristics, including higher thermal stability, resistance to serum inactivation in vivo, and the ability to infect both dividing and non-dividing cells with high efficiencies. Another significant patent is "A Novel Rnai Molecule Delivery Platform Based On Single-Sirna And Shrna Nanocapsules." This invention discloses robust and effective siRNA and shRNA nanocapsules and delivery methods, providing a platform for RNAi delivery with low toxicity and a long intracellular half-life for practical therapeutic applications.
Career Highlights
Irvin Sy Chen has worked at prestigious institutions, including the California Institute of Technology and the University of California. His contributions to the field of gene therapy and RNA delivery systems have garnered attention and recognition.
Collaborations
Chen has collaborated with notable figures in the scientific community, including David Baltimore and Xiao-Feng Qin. These collaborations have further advanced his research and innovations in the field.
Conclusion
Irvin Sy Chen is a pioneering inventor whose work in gene therapy and RNA delivery systems has the potential to revolutionize therapeutic applications. His innovative approaches and collaborations continue to contribute significantly to advancements in medical science.