Location History:
- New Orleans, LA (US) (2003 - 2008)
- Baltimore, MD (US) (2009)
Company Filing History:
3 out of 824 
1 out of 45 
1 out of 2,971 
Years Active: 2003-2009
Title: Innovations and Contributions of Inventor Iris Lindberg
Introduction
Iris Lindberg is a prominent inventor based in New Orleans, LA (US). She has made significant contributions to the field of molecular studies, particularly in the development of peptides and gene targeting methods. With a total of 4 patents, her work has implications for therapeutic uses in various medical fields.
Latest Patents
One of her latest patents focuses on inhibiting furin with polybasic peptides. This invention discloses small, polybasic peptides that are effective as furin inhibitors, specifically hexa- to nona-peptides containing L-Arg or L-Lys in most positions. The removal of peptide terminating groups can enhance the inhibition of furin. High inhibition levels were observed in a series of non-amidated and non-acetylated polyarginines. The most potent inhibitor identified to date, nona-L-arginine, exhibited a Kagainst furin of 40 nM. Non-acetylated, poly-D-arginine-derived molecules are preferred for therapeutic applications, such as inhibiting certain bacterial infections, viral infections, and cancers. Due to their relatively small size, these peptides are expected to be non-immunogenic and can be efficiently transported across cell membranes.
Another significant patent involves 7B2 knockout transgenic animals as models of endocrine disease. This invention features methods and uses for transposon-mediated gene targeting, which greatly enhance the insertion and detection of desired genes in genomic exons through homologous recombination. It also includes transgenic non-human mammals and eukaryotic cells, wherein a gene encoding 7B2 protein is modified. The invention provides nucleic acid vectors capable of undergoing homologous recombination with an endogenous 7B2 gene in a cell. Furthermore, it features transgenic non-human mammals as models for endocrine disorders, along with methods for diagnosing and treating patients with these disorders.
Career Highlights
Iris Lindberg has worked with notable institutions such as Louisiana State University and Agricultural & Mechanical College and Torrey Pines Institute for Molecular Studies. Her research has significantly advanced the understanding of molecular mechanisms in health and disease.
Collaborations
Iris has collaborated with esteemed colleagues, including Angus Cameron and Richard Allen Houghten, contributing to her innovative research and development efforts.
Conclusion
Iris Lindberg's contributions to