The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 2006
Filed:
Jul. 16, 2001
Iris Lindberg, New Orleans, LA (US);
Angus Cameron, Bristol, GB;
Jon Appel, Cardiff, CA (US);
Richard Houghten, Solana Beach, CA (US);
Iris Lindberg, New Orleans, LA (US);
Angus Cameron, Bristol, GB;
Jon Appel, Cardiff, CA (US);
Richard Houghten, Solana Beach, CA (US);
Board of Supervisors of Louisiana State University and Agriculture and Mechanical College, Baton Rouge, LA (US);
Abstract
Small, polybasic peptides are disclosed that are effective as furin inhibitors, e.g. hexa- to nona-peptides having L-Arg or L-Lys in most positions. Removing the peptide terminating groups can improve inhibition of furin. High inhibition was seen in a series of non-amidated and non-acetylated polyarginines. The most potent inhibitor identified to date, nona-L-arginine, had a Kagainst furin of 40 nM. Non-acetylated, poly-D-arginine-derived molecules are preferred furin inhibitors for therapeutic uses, such as inhibiting certain bacterial infections, viral infections, and cancers. Due to their relatively small size, these peptides should be non-immunogenic. These peptides are efficiently transported across cell membranes.