Company Filing History:
2 out of 5,444 
2 out of 5 
1 out of 1 Years Active: 1999-2003
Title: Innovations in Telomerase Modulation by Ira Maine
Introduction
Ira Maine is an accomplished inventor based in San Antonio, TX (US). He has made significant contributions to the field of cancer research through his innovative work on telomerase modulation. With a total of 4 patents, Maine's discoveries have the potential to impact cancer treatment significantly.
Latest Patents
Maine's latest patents focus on methods for modulation and inhibition of telomerase. His research indicates that normal human stem cells produce a regulated non-processive telomerase activity, while cancer cells exhibit a processive telomerase activity. He discovered that nucleotide analogs, such as 7-deaza-2'-deoxyquanosine-5'-triphosphate (7-deaza-dGTP), serve as substrates for processive telomerase and can be incorporated into telomeric sequences. This incorporation affects the processivity of telomerase, converting it from a processive to a non-processive form. Additionally, these nucleotide analogs inhibit the formation of G-quartets by telomeric sequences. Other methods identified by Maine include partially cleaving the telomerase RNA to convert cancer processive telomerase to the more benign non-processive form. His findings reveal that nucleoside analogs can mediate allosteric-like inhibition of telomerase, lead to premature termination and shortening of telomeric DNA, destabilize telomeric structure and function, and ultimately result in cell death. Understanding the mechanisms of telomerase modulation by the 7-deaza-nucleotides has facilitated the design of new telomerase inhibitors and modulators, which have applications in cancer treatment.
Career Highlights
Maine has worked with notable institutions, including the University of Texas System and the CTRC Research Foundation. His work has been pivotal in advancing the understanding of telomerase and its implications in cancer biology.
Collaborations
Maine has collaborated with esteemed colleagues such as Shih-Fong Chen and Terace M Fletcher, contributing to the collective knowledge in the field of telomerase research.
Conclusion
Ira Maine's innovative research on telomerase modulation represents a significant advancement in cancer treatment strategies. His work continues to inspire further exploration in the field of cancer biology and therapeutic development.
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