Ian Goodsell

Title: Ian Goodsell: Innovator in Protein Disulfide Isomerase Research

Introduction

Ian Goodsell is a notable inventor based in Sandy, Utah, recognized for his contributions to the field of biochemistry. He holds a patent that focuses on protein disulfide isomerase, a crucial component in the study of venom ducts. His work has implications for understanding and manipulating disulfide-rich peptides.

Latest Patents

Ian Goodsell's patent, which he holds, is titled "Protein disulfide isomerase is a major component of venom ducts." This invention relates to a protein disulfide isomerase (PDI) derived from snails, along with a nucleic acid sequence encoding the protein. The patent outlines methods for folding disulfide-rich peptides using PDI. Notably, the oxidative folding of conotoxin precursors, catalyzed by PDI, was found to be more efficient, reducing the number and concentration of transiently accumulated folding species. The influence of the propeptide relative to the mature peptide on PDI-assisted oxidative folding of conotoxins is also highlighted in his work.

Career Highlights

Throughout his career, Ian has worked with esteemed organizations such as the University of Utah Research Foundation and Cognetix, Inc. His research has significantly advanced the understanding of protein folding mechanisms, particularly in the context of venomous species.

Collaborations

Ian Goodsell has collaborated with notable scientists in his field, including Grzegorz Bulaj and Baldomero M. Olivera. These collaborations have further enriched his research and contributed to the advancement of biochemistry.

Conclusion

Ian Goodsell's innovative work in protein disulfide isomerase research has made a significant impact in the field of biochemistry. His contributions continue to influence the understanding of protein folding and its applications in various scientific domains.