The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2007
Filed:
Aug. 31, 2005
Grzegorz Bulaj, Salt Lake City, UT (US);
Baldomero M. Olivera, Salt Lake City, UT (US);
Olga Buczek, Salt Lake City, UT (US);
James E. Garrett, Salt Lake City, UT (US);
Ian Goodsell, Sandy, UT (US);
Grzegorz Bulaj, Salt Lake City, UT (US);
Baldomero M. Olivera, Salt Lake City, UT (US);
Olga Buczek, Salt Lake City, UT (US);
James E. Garrett, Salt Lake City, UT (US);
Ian Goodsell, Sandy, UT (US);
University of Utah Research Foundation, Salt Lake City, UT (US);
Cognetix, Inc., Salt Lake City, UT (US);
Abstract
Protein disulfide isomerase is a major component ofvenom ducts. The invention relates to a protein disulfide isomerase (PDI) fromsnails, a nucleic acid sequence encoding theprotein disulfide isomerase, and to methods for folding disulfide-rich peptides using a protein disulfide isomerase. Oxidative folding of conotoxin precursors, catalyzed by a PDI, was more efficient and decreased the number and concentration of transiently accumulated folding species. The PDI-assisted oxidative folding of conotoxins was also influenced by the propeptide relative to the mature peptide.