Location History:
- Brier, WA (US) (1997)
- Middle Dural, AU (1998)
Company Filing History:
Years Active: 1997-1998
Title: Ian E Alexander: Innovator in Gene Therapy
Introduction
Ian E Alexander is a notable inventor based in Brier, Washington. He has made significant contributions to the field of gene therapy, particularly in enhancing the efficiency of viral vectors used for gene delivery. His work is crucial for advancing treatments in various medical conditions.
Latest Patents
Ian E Alexander holds 2 patents, with his latest invention titled "Method for increasing transduction of cells by adeno-associated virus." This invention includes methods for increasing the efficiency of transduction of cells, including non-dividing cells, by recombinant AAV vectors. The methods utilize agents that alter certain aspects of DNA metabolism, specifically affecting DNA synthesis and repair, which impacts the maintenance of chromosomal integrity and can cause damage to cellular DNA. The agents and vectors can be preselected and screened for their transducing ability and their effect on DNA metabolism. Some of the agents include tritiated nucleotides such as thymidine, gamma irradiation, UV irradiation, cis-platinum, etoposide, hydroxyurea, and aphidicolin.
Career Highlights
Ian E Alexander is affiliated with the Fred Hutchinson Cancer Center, where he continues to work on innovative solutions in gene therapy. His research is pivotal in the ongoing efforts to improve gene delivery systems, which can lead to more effective treatments for various diseases.
Collaborations
Some of his notable coworkers include David W Russell and A Dusty Miller, who contribute to the collaborative research environment at the Fred Hutchinson Cancer Center.
Conclusion
Ian E Alexander's work in gene therapy exemplifies the innovative spirit of modern science. His patents and research efforts are paving the way for advancements in medical treatments, showcasing the importance of innovation in healthcare.