This inventor holds 1 USPTO granted patent and 1 EPO patent. Top assignee: Development Center for Biotechnology. Active years: 2020.
Company Filing History:
Years Active: 2020
Title: The Innovative Contributions of I-Ling Kou
Introduction
I-Ling Kou is a notable inventor based in Xizhi, Taiwan. He has made significant contributions to the field of biotechnology, particularly in vaccine development. His innovative work has led to advancements in immunogenicity and the effectiveness of vaccines against enterotoxigenic bacteria.
Latest Patents
I-Ling Kou holds a patent for "Polysaccharide conjugation with detoxified heat labile enterotoxin (LT) used as vaccine." This invention utilizes a detoxified recombinant heat-labile enterotoxin mutant, LTS61K, as a carrier protein to conjugate polysaccharides. The LTS61K contains a mutated mature sub-unit A (LTA) that includes lysine at amino acid position 61 and a wild-type mature sub-unit B (LTB). Various types of bacterial capsular polysaccharide antigens were chemically conjugated with the LTS61K protein through a reductive amination reaction. The resulting conjugated polysaccharide-LTS61K products were identified as soluble forms. Immunization studies in rabbits demonstrated that these conjugated vaccines induce higher polysaccharide-specific IgG titers and greater bactericidal activity compared to polysaccharide alone or polysaccharide mixed with LTS61K. The presence of anti-LTS61K serum IgG antibody has been shown to alleviate travel diarrhea caused by enterotoxigenic E. coli (ETEC).
Career Highlights
Throughout his career, I-Ling Kou has worked with various organizations, including the Development Center for Biotechnology and DCB-USA LLC. His work has been instrumental in advancing vaccine technology and improving public health outcomes.
Collaborations
I-Ling Kou has collaborated with notable colleagues such as Kuo-Chan Hung and Yuan-Hsin Lu. These partnerships have contributed to the success of his research and innovations in the field.
Conclusion
I-Ling Kou's contributions to vaccine development and biotechnology highlight his role as an influential inventor. His innovative approaches to immunogenicity and vaccine efficacy continue to impact the field positively.