This inventor holds 5 USPTO granted patents. Top assignee: California Institute of Technology. Active years: 2008-2017.
Company Filing History:
Years Active: 2008-2017
Title: Hwan-Ching Tai: Innovator in Protein Glycosylation Detection
Introduction
Hwan-Ching Tai is a notable inventor based in Pasadena, CA (US), recognized for his contributions to the field of protein glycosylation detection. With a total of 5 patents, Tai has made significant advancements in methods that enhance the sensitivity and rapidity of detecting post-translationally modified proteins.
Latest Patents
One of Tai's latest patents focuses on a method and compositions for the detection of protein glycosylation. This invention provides innovative techniques for the rapid and sensitive detection of post-translationally modified proteins, particularly those with glycosylations. The methods are capable of detecting O-GlcNAc posttranslational modifications on proteins that were previously undetectable using traditional techniques. The method utilizes an engineered mutant of β-1,4-galactosyltransferase to selectively transfer an unnatural ketone functionality onto O-GlcNAc glycosylated proteins. This ketone moiety serves as a versatile handle for biotin attachment, enabling the detection of modified proteins. The approach allows for the rapid visualization of proteins that are at the limits of detection with conventional methods. Furthermore, the preferred embodiments of this invention can be applied to detect various disease states, including cancer, Alzheimer's disease, neurodegeneration, cardiovascular disease, and diabetes.
Career Highlights
Hwan-Ching Tai is affiliated with the California Institute of Technology, where he continues to innovate and contribute to scientific research. His work has garnered attention for its potential applications in medical diagnostics and therapeutic developments.
Collaborations
Tai collaborates with esteemed colleagues, including Sabine Arndt and Nelly Khidekel, who contribute to the advancement of research in protein glycosylation.
Conclusion
Hwan-Ching Tai's innovative work in the detection of protein glycosylation represents a significant leap forward in biomedical research. His contributions have the potential to impact the diagnosis and treatment of various diseases, showcasing the importance of innovation in the scientific community.