Company Filing History:
Years Active: 2010-2013
Title: The Innovations of Inventor Hui-Fen Zhao
Introduction: Hui-Fen Zhao is an accomplished inventor based in LaSalle, California. With a total of two patents, he has been a driving force in the field of gene expression systems. His innovative approaches to biotechnology have garnered attention and recognition from both academic and research institutions.
Latest Patents: Hui-Fen Zhao's latest invention involves a coumermycin/novobiocin-regulated gene expression system. This groundbreaking technology features a chimeric transactivator that combines a transcription activation domain, a repressor protein DNA binding domain, and the bacterial DNA gyrase B subunit. A target gene is operatively linked to operator DNA sequences recognized by the repressor binding domain. The system is designed such that the addition of the antibiotic coumermycin leads to a coumermycin-switched dimerization of the transactivator, allowing it to bind to operator DNA sequences and activate the transcription of the target gene. Furthermore, the introduction of novobiocin can deactivate the expression of the target gene by preventing the coumermycin-induced dimerization of the transactivator.
Career Highlights: Hui-Fen Zhao has developed a strong career in biotechnology and gene expression research. He works at the National Research Council of Canada, where his expertise continues to contribute to significant advancements in the field. His noteworthy work ensures that he remains a respected figure in the science and technology community.
Collaborations: Throughout his career, Hui-Fen Zhao has had the privilege of collaborating with talented individuals such as Shi-Hsiang Shen. Their cooperative efforts have led to valuable insights and innovation within their projects.
Conclusion: Hui-Fen Zhao's contributions to the field of biotechnology exemplify the spirit of innovation and dedication to advancing our understanding of gene expression systems. His patents represent significant milestones in this area, promising exciting possibilities for future research and applications.