Huayue Li

Title: Innovations by Huayue Li: Pioneering Enzyme and Prenyltransferase Research

Introduction

Huayue Li is an accomplished inventor based in Shandong, China. He has made significant contributions to the field of biochemistry, particularly in the development of enzymes and their applications in drug development. With a total of three patents to his name, Li's work is paving the way for advancements in pharmacological research.

Latest Patents

One of Huayue Li's latest patents is titled "Enzyme with acyl transfer function and application thereof." This invention describes an enzyme that possesses an acyl transfer function, characterized by an amino acid sequence identical to a specific SEQ ID NO. The enzyme is capable of acylation modification for various macrolide compounds, including macrolactins, filipins, chloramphenicol, and glycosylated piericidin A. The application of this acyltransferase allows for the binding of an acyl group from an acyl donor to these macrolide compounds, enhancing their pharmacological activity and bioavailability while reducing toxicity and side effects. This innovation presents a new strategy for the drug development of macrolide compounds.

Another notable patent by Li is the "Method for assembling prenyl groups onto cyclic dipeptides." This invention introduces a novel PSL family prenyltransferase that exhibits relaxed substrate specificity. It can utilize various cyclic dipeptides and prenyl donors to produce diverse terpenylated diketopiperazines. The amino acid sequence of this prenyltransferase is designated as SEQ ID NO: 1. The application of this enzyme facilitates the transfer of different prenyl groups to Trp-containing cyclic dipeptides, thereby catalyzing the formation of terpenylated diketopiperazines. This method offers a new approach for drug development in diketopiperazines.

Career Highlights

Huayue Li has worked at prominent institutions, including Ocean University of China. His research and innovations have garnered attention in the scientific community, contributing to advancements in biochemistry and pharmacology.

Collaborations

Li has collaborated with notable colleagues such as Wenli Li and Tingting Yao. Their combined efforts in research have furthered the understanding and application of enzymes in drug development.

Conclusion

Huayue Li's innovative work in enzyme research and drug development showcases his significant contributions