Huan Liu

Title: Huan Liu: Innovator in Antitumor Drug Delivery Systems

Introduction

Huan Liu is a prominent inventor based in Tianjin, China. He has made significant contributions to the field of antitumor drug delivery systems. His innovative work focuses on enhancing the efficacy and targeting of antitumor drugs, which is crucial in cancer treatment.

Latest Patents

Huan Liu holds a patent for a "Ternary conjugate of antitumor drug, and synthesis and application." This patent discloses a targeted delivery system for a hydrophobic antitumor drug. The system involves conjugates of E-selectin polypeptide ligand, polyethylene glycol, and the antitumor drug, connected by different link bridges containing disulfide bonds. The patent details the synthesis of these conjugates, evaluation of their antitumor activity, and the characteristics of nanoparticles self-assembled from the conjugates in an aqueous solution. The conjugates are designed to actively target tumor sites through the E-selectin peptide ligand and can self-assemble into nanoparticles, allowing for passive targeting via the enhanced permeability and retention (EPR) effect. The results indicate that these conjugates exhibit significant antitumor activity while being less toxic to normal cells. They also inhibit the adhesion between tumor cells and vascular endothelial cells, showcasing potential in anti-tumor metastasis and broad prospects for the development and application of antitumor drugs.

Career Highlights

Huan Liu is affiliated with Tianjin University of Science and Technology, where he conducts his research and development work. His innovative approach to drug delivery systems has positioned him as a key figure in the field of cancer treatment.

Collaborations

Huan Liu collaborates with notable colleagues, including Peng Yu and Na Guo. Their combined expertise contributes to the advancement of research in antitumor drug delivery systems.

Conclusion

Huan Liu's contributions to the field of antitumor drug delivery systems highlight the importance of innovation in cancer treatment. His patented work demonstrates significant potential for improving therapeutic outcomes for patients.